Vitamin C supplementation prevents Developmental Bone Disease in large and giant breed dogs.

Vitamin C is important in the synthesis of collagen, which is the most widely distributed tissue in the body. However, there are no known dietary requirements for Vitamin C in dogs, as dogs can synthesize their own Vitamin C from glucose in their liver.

Diets completely lacking in Vitamin C fed to growing puppies for 150 days had no adverse effects on their growth or skeletal structures. Conversely, no advantage has been seen in scientific studies when animals at risk for Developmental Bone Disease were given high doses of Vitamin C through the growth stage.

If you have more specific questions - Ask the Nutritionist.